Abstract
Cardiovascular diseases are one of the leading causes of death across the globe. Heart transplantation has been used for end stage heart failure patients. However, due to the lack of donors, this treatment option usually depends on multiple variables and the result varies due to immunological issues. 3D bioprinting is an emerging approach for in vitro generation of functional cardiac tissues for drug screening and cardiac regenerative therapy. There are different techniques such as extrusion, inkjet, or laser-based 3D printing that integrate multiple cell lines with different scaffolds for the construction of complex 3D structures. In this review, we discussed the recent progress and challenges in 3D bioprinting strategies for cardiac tissue engineering, including cardiac patches, in vitro cardiac models, valves, and blood vessels.
Highlights
Cardiovascular diseases (CVD) are common, enervating and fatal malady that devours thousands of life every year (Huang et al, 2021; Mei et al, 2021)
This review provides an overview of cardiovascular 3D bioprinting techniques, their potential applications, limitations and the future prospects of this new technology (Figure 1)
This study provides a proof that the hybrid hydrogels mimic layer specific valve extracellular matrix (ECM) and are a good choice for heart valve tissue engineering (Duan, et al, 2013)
Summary
Cardiovascular diseases (CVD) are common, enervating and fatal malady that devours thousands of life every year (Huang et al, 2021; Mei et al, 2021). Mounting evidence suggested that stem cell therapies demonstrate treatment benefit through cardiac function enhancement, infract size reduction, and angiogenesis improvement (Su et al, 2018; Huang et al, 2018; Su et al, 2019; Huang K. et al, 2020; Cheng et al, 2012b). They are hampered by the intrinsic limitations after transplantation, such as low cell retention, low survival rate of the engrafted cells and lack of host tissue integration (Wang and Guan, 2010; Ong et al, 2017).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
