Abstract
Demand for donor hearts has increased globally due to cardiovascular diseases. Recently, three-dimensional (3D) bioprinting technology has been aimed at creating clinically viable cardiac constructs for the management of myocardial infarction (MI) and associated complications. Advances in 3D bioprinting show promise in aiding cardiac tissue repair following injury/infarction and offer an alternative to organ transplantation. This article summarizes the basic principles of 3D bioprinting and recent attempts at reconstructing functional adult native cardiac tissue with a focus on current challenges and prospective strategies.
Highlights
Mortality due to cardiovascular disease (CVD) has been on a global incline due, in large part, to a shortage of donor organ supply
New heart transplant listings increased by 57% between 2005 and 2016 while the number of patients waiting to undergo heart transplantation increased by 127% over the same period; showing an increasing demand for donor hearts [3]
Many hurdles exist in achieving successful heart transplantation including procurement of the donor heart and post-transplant organ rejection
Summary
Mortality due to cardiovascular disease (CVD) has been on a global incline due, in large part, to a shortage of donor organ supply. Heart transplantation is often needed to treat CVD because the heart tissue is unable to regenerate cardiomyocytes. A lack of blood flow to the myocardium (myocardial infarction) results in scarring and permanent loss of cardiomyocytes which can
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Materials Science: Materials in Medicine
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
