3D Atlas of adult zebrafish brain development

Abstract

Event Abstract Back to Event 3D Atlas of adult zebrafish brain development Peng Yang1*, Gerda Lamers1, Ron Bout1 and Fons Verbeek1 1 Leiden University, Netherlands The zebrafish (Danio rerio) is an important model system in developmental genetics and vertebrate developmental biology. Over last two decades, several organizations had investigated zebrafish in many different aspects. Three dimensional atlases of the zebrafish have been constructed. On top of the atlases that we have developed, an atlas of the adult zebrafish brain has designed. We have used different imaging modalities so that it can be matched to different kinds of experimental work. The relative small size compared to other vertebrates (e.g. mouse, rat) is provides a challenge in the composition of the, multimodal zebrafish brain studies.The two key elements in the construction of the atlas are the high resolution image acquisition approaches and improved 3D reconstruction software tools. There are two main approaches to obtain brain images, stained physical sections and other in vivo methods.We have built a 3D atlas model of adult zebrafish brain using 3D reconstruction software tools, TRD-3Dbase (http://bio-imaging.liacs.nl/tdr3dbase.html). The models are obtained from three different imaging approaches, stained section images, Magnetic Resonance Microscopy (MRM) images (http://www.ssnmr.leidenuniv.nl) and Synchrotron X-ray Tomographic Microscopy (SRX-ray) images (http://www.biomed.ee.ethz.ch/research/x-ray_microscopy). The modalities are glued together through specific ontology terms; initially, we have restricted to structures that could be visualized in either of the tree modalities. This atlas supports 3D understanding of the structures in adult zebrafish brain more easily. In the future we will further zoom into the specific resolutions of the different modalities and resolve the more complex structures. Conference: Neuroinformatics 2009, Pilsen, Czechia, 6 Sep - 8 Sep, 2009. Presentation Type: Poster Presentation Topic: Digital atlasing Citation: Yang P, Lamers G, Bout R and Verbeek F (2019). 3D Atlas of adult zebrafish brain development. Front. Neuroinform. Conference Abstract: Neuroinformatics 2009. doi: 10.3389/conf.neuro.11.2009.08.011 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 21 May 2009; Published Online: 09 May 2019. * Correspondence: Peng Yang, Leiden University, Leiden, Netherlands, pengyang@liacs.nl Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Peng Yang Gerda Lamers Ron Bout Fons Verbeek Google Peng Yang Gerda Lamers Ron Bout Fons Verbeek Google Scholar Peng Yang Gerda Lamers Ron Bout Fons Verbeek PubMed Peng Yang Gerda Lamers Ron Bout Fons Verbeek Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.