Abstract
Telomerase (human telomerase reverse transcriptase (hTERT) is considered a hallmark of cancer, being active in cancer cells, but repressed in human somatic cells. It was recently identified as a potential target for anti-cancer immunotherapy. Exosomes are nano-sized particles secreted from all types of cells, containing a molecular cargo that reflects their cells of origin. Exosomal hTERT mRNA can be detected in the serum of patients with solid malignancies, but not in healthy individuals. We sought to evaluate the feasibility of measuring serum exosomal hTERT transcripts levels in patients with lung cancer at diagnosis and during the course of their disease.
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