398 Differential UV-induced cytokine expression in dependence to skin microbiome in Polymorphic Light Eruption

Abstract

Polymorphic light eruption (PLE) is a chronic intermittent skin disease that develops episodes after sun exposure, most often in spring or early summer. Although the pathogenesis is not fully understood, evidence indicates that the skin microbiome may play a crucial role. Preclinical data have shown that the skin microbiome can regulate UV-induced cytokine expression and modulate the subsequent immune response. We therefore hypothesized that the skin microbiome of PLE patients might modulate cytokine expression after sun exposure.