397 Risk factors related to locoregional recurrence in squamous cell carcinoma of the skin

Abstract

A retrospective analysis was performed in order to identify the risk factors associated with development of locoregional recurrent disease in patients with primary squamous cell carcinoma of the skin. Step-wise logistic regression analysis was used which consisted of 1039 patients treated from January 1980 to December 1989 at Ankara Oncology Hospital. Locoregional recurrence occurred in 187 (18%) of these patients within a mean disease-free period of 15 months. Age, sex, anatomical location, size of lesion, lymph node status at diagnosis, stage according to TNM classification, histopathologic differentiation, prior therapy, treatment modality, lesions arising from scar tissue (scar carcinoma), concomitant premalignant tumor of the skin, development of secondary non-melanotic skin carcinoma and second malignancy were used as variables which could be correlated with locoregional recurrent disease. No correlation was found between development of recurrence and prior treatment, second non melanoma skin cancer, second malignancy, premalignant skin tumor, sex or regional lymph node dissection. Although univariate analysis demonstrated that location, size, lymph node status, stage, histologic differentiation, scar carcinoma and treatment modality were associated with an increased risk of locoregional recurrence, it was found out that stage of the disease (P