#3935 AUDIOLOGICAL ASSESSMENT IN PEDIATRIC CKD PATIENTS

Abstract

Abstract Background and Aims Many similarities exist between the nephron & ear infrastructures, making them vulnerable to same risk factors. Idiopathic sensory neural hearing loss is frequent in pediatric patients with chronic kidney disease (CKD). Our aims were to determine the prevalence, type, & degree of hearing impairment in pediatric CKD patients. Method This cross-sectional study was carried out at pediatric dialysis & nephrology unit at Children's hospital & Audiology unit, Faculty of Medicine Ain Shams University, included 45 CKD patients’ stage 2-4, 45 CKD patients’ stage 5 on hemodialysis, & 90 children as controls. Detailed history, physical, otological examinations & audiological assessment by standard pure tone audiometry, speech audiometry & tympanometry, IQ test, in addition to some laboratory investigations were done for all our studied patients. Results The mean IQ was significantly lower in CKD patients than the controls, however, it was significantly higher in dialysis than non-dialysis groups (p = 0.05). Pure tone audiometry showed 16.6% of out CKD patients had hearing loss, which was mainly sensory neural (SNHL); (53.3%), that was significantly higher compared to the control group (p < 0.001). A mild degree of high-frequency hearing loss was frequently reported. These findings weren't significantly different between dialysis & non-dialysis patients, but were significant compared to control group (P<0.001). Regarding speech discrimination scores, controls had a higher significant change compared to CKD patients. Regarding Tympanometry test results, most of CKD patients & the controls had normal middle ear pressure. The most determining factor affecting the hearing loss in our patients was the IQ. Conclusion High-frequency SNHL is not uncommon in CKD pediatric patients, in addition to low IQ. It's recommended to do a routine audiological evaluation & follow up for early diagnosis & intervention.