393 Low-Intensity Shockwave Therapy for the Treatment of Erectile Dysfunction

Abstract

Low-Intensity Shockwave Therapy (LISWT) may improve erectile function in patients with erectile dysfunction (ED). Currently, there remains a paucity of research and prospective data on the utilization of LISWT in patients whom experience ED. The purpose of this Phase II clinical trial is to evaluate the safety and potential efficacy of this novel therapy. We present our results with an initial cohort of patients. We obtained IRB approval and prospectively enrolled patients (n=25) with erectile dysfunction. Treatment consisted of the application of 3300 shocks (0.16mJ/mm2) each to the bilateral corpora cavernosa and the bilateral crura. Full treatment course included six weekly treatment sessions and a one-month post-treatment evaluation. IIEF and EDITS scores were obtained at baseline and one month after the treatment course concluded. Duplex penile ultrasound assessed peak systolic velocity (PSV) of the cavernosal arteries at baseline and one-month post-treatment. Statistically significant differences in IIEF, EDITS and PSV pre and post-treatment were evaluated using Fisher’s exact test for categorical variables and either Wilcoxon sign rank or Kruskall-Wallis ANOVA for continuous variables. Treatment success was defined as a clinically significant increase in IIEF-6 from baseline, an overall EDITS index score greater than 65 or an increase in EDITS index score greater than 10 points.