Abstract
391 Upregulation of Phosphodiesterase Type 4 in the Hyperplastic Prostate
Highlights
Study we used a rat BPH model and human hyperplastic prostate tissue to investigate the expression of genes involved in the major pathways regulating SM tone, with PDE5 emphasized
In parallel with previous observations[11,12], T injection mainly led to a notable involution of acinar epithelium hyperplasia, such as increased acinus amount, papillary fronds protruding into the glandular cavities and thickening of the epithelial layer while the stromal compartment was relatively decreased
Wang et al recently found PDE5 was expressed in both acinar epithelium as well as periacinar SM and lobe-specific PDE5 expression patterns were observed in this study[13]
Summary
Bladder weight (mg) study we used a rat BPH model and human hyperplastic prostate tissue to investigate the expression of genes involved in the major pathways regulating SM tone, with PDE5 emphasized. The testosterone (T)-supplementation rat model of BPH was validated through increased weight of the ventral prostate and seminal vesicle (Fig. 1 and Table 1, P < 0 .001) by 1.6-fold and 2-fold, respectively. Differential histopathology was observed between human and rat BPH by H-E and Masson’s trichrome staining.
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