Abstract
PHERIC-1 is an italian multicenter, double-blind, placebo-controlled trial aimed to investigate the safety and the hemodynamic effects of sustained sildenafil (Sld) administration in COPD-associate out-of-proportion pulmonary hypertension (COPD-OoPPH) (http://clinicaltrials.gov/ct2/show/NCT01441934). Primary end-points: reduction in pulmonary vascular resistance (PVR), and drop in PaO2. ITT analysis of the results is presented.
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