391 A first-in-human study of intratumoral SAR441000, an mRNA mixture encoding IL-12sc, interferon alpha2b, GM-CSF and IL-15sushi as monotherapy and in combination with cemiplimab in advanced solid tumors

Oliver Bechter,Rahul Marpadga,Marie-Laure Ozoux,Christophe Massard,Ugur Sahin,Nicolas Acquavella,Carmen Loquai,Evelyna Derhovanessian,Jochen Utikal,Esteban-Rodrigo Imedio,Jean-Francois Baurain

doi:10.1136/jitc-2020-sitc2020.0391

391 A first-in-human study of intratumoral SAR441000, an mRNA mixture encoding IL-12sc, interferon alpha2b, GM-CSF and IL-15sushi as monotherapy and in combination with cemiplimab in advanced solid tumors

Oliver Bechter, Rahul Marpadga + Show 9 more

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https://doi.org/10.1136/jitc-2020-sitc2020.0391

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Journal: Journal for ImmunoTherapy of Cancer	Publication Date: Nov 1, 2020
Citations: 6	License type: open-access

Affiliation: Sanofi (United States), Institut Gustave Roussy, University of Paris-Saclay, Institut Polytechnique de Paris, University Medical Center of the Johannes Gutenberg University Mainz, Johannes Gutenberg University Mainz, BioNTech (Germany), Heidelberg University

#Non-injected Tumors #T-cell Infiltration + Show 8 more

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Abstract

BackgroundmRNA-based-drugs can be applied for cancer immunotherapy.1 SAR441000 is a novel saline-formulated mixture of four mRNAs encoding interleukin-12 single chain, interferon alpha-2b, granulocyte-macrophage colony-stimulating factor, and interleukin-15 sushi that we...

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