Abstract
Publisher Summary 10-Carboxymethyl-9-acridanone (CMA) is a small-molecular-weight compound structurally related to the acridines. It has been shown to induce very high titers of interferon in mice when given intraperitoneally (IP), subcutaneously (SC), intramuscularly (IM), intravenously (IV), or orally and to be effective in protecting mice against lethal infections with several RNA and DNA viruses but without effect in cell culture. The compound is unique among small molecular weight, nonviral interferon inducers because of the high titers of interferon induced and because, unlike tilorone, CMA, under the conditions studied thus far, does not induce a hyporeactive state to interferon induction. The interferon induced by CMA is similar to virus-induced interferon. The interferon is resistant to pH 2, nonsedimentable, and sensitive to trypsin and heat treatment; it is not expressed in the presence of actinomycin D. The molecular weight of CMA-induced mouse plasma interferon is determined to be 25,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. These parameters are the same as for bluetongue virus-induced mouse plasma interferon analyzed simultaneously.
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