38P Tumour-infiltrating lymphocytes and correlation with prognostic signature scores in early-stage hormone-positive, HER2-negative (ER+/HER2-) breast cancer

Abstract

Tumour infiltrating lymphocytes (TILs) in triple-negative and HER2-positive breast cancer has been associated in higher responses to treatment and potentially a prognostic marker. Hormone-positive, HER2-negative (ER+/HER2-) breast cancer is considered a less immunogenic tumour and the role of TILs in this cohort is less clear, partly due to the lack of data. We aimed to assess overall number of CD45-positive tumour-infiltrating lymphocytes in early-stage, ER+/HER2- breast cancer and its relationship with proliferation index, grade, menopausal status and the 21-gene recurrence score.