Abstract

Ductal carcinoma in situ (DCIS) of the breast is a heterogeneous disease in terms of morphology and genetics. Tumor architecture and cellular morphology classify DCIS into subgroups to guide clinical management. This leaves a large portion of histopathological features (HPF) uncharacterized. This study explored the extent of heterogeneity of nuclear atypia, DCIS architecture, necrosis, calcifications, stromal architecture and stromal inflammation between biopsies and their subsequent resection specimen in DCIS.

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