Abstract
Genetic variations in quantitative traits are remarkably complex. Moreover, it is more challenging to detect causative genetic variation because small effects mainly influence quantitative traits. The objective of this study is to search for markers that are significantly involved in carcass traits using missense mutations in which single nucleotide polymorphisms (SNPs) change amino acids. Genomic region-specific association test used missense variants and carcass traits of 16,970 Hanwoo. As a result, 222, 98, 142, and 119 significant SNPs were found in association with carcass weight (CW), backfat thickness (BFT), eye muscle area (EMA), and marbling score (MS), respectively. The most significant marker was the same in the results of CW and EMA, which was located at 19,524,263 on chromosome 14 involving the PRKDC gene. Four candidate genes were newly discovered for MS. The SNPs identified in this study will be useful markers for carcass traits in Hanwoo commercial farms.
Published Version
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