381 - Study of Triple Negative Breast Cancer and Lymph Node Involvement Among Eastern Indian Patients- An Institutional Experience

Abstract

ABSTRACT Background Breast Cancer is the most commonly diagnosed cancer among Indian women. Recent reports from India suggest a significant increase in the incidence of Estrogen and Progesterone receptor negative (ER-/PR-) breast cancer. Recently the targeted therapies improving the prognosis, so, know about receptor status becoming important. Yet very little is known about the specific histological subtypes or receptor status of breast cancer in women of eastern India. So a hospital based study was undertaken. Objectives This study was conducted to understand the frequency of occurrence of specific breast cancer subtypes and risk factors associated with the age, histologic subtypes among the patients and find the clinical features in relation to receptor status. Methods 224 breast cancer patients, who are operated during the period of Mar 2009 to Nov 2011 from our cancer hospital, were selected for the study. Personal history (i.e. Age, age of Menarche and menopause status etc), case report and histopathology report were analyzed. Statistical analysis was performed using Software SPSS version 16.0 Results Average age of the Patients 46.9 ± 1.32 Invasive- Ductal 66.51% Invasive- Lobular 10.71% Others (Fibrodenoma, infiltrating duct carcinoma etc.) 22.76% Tumor Grade Grade I 13.83% Grade II 54.46 % Grade III 31.69% Average Lymph Node Size 1.85 c.m ± 0.09 ER-/PR- Breast Cancer 45.53% ER-/PR-/Her2neu- (Triple Negative) 23.21% Average lymph node number of Triple negative cancer patients 12 ±0.54 Among the triple negative patients average age 44.9 ± 3.24 Average lymph node number of without Triple negative cancer patients 5.71 ±0.44 Her2neu+ 56.25% Conclusions Invasive Ductal carcinoma is very common among the eastern Indian patients. Maximum patients contains Garde II tumor. Among ER, PR negative breast cancer patient 50% does not possess Her2Neu receptor (triple negative). The Triple negative cancer patients contain a significantly high number of Lymph node (p Disclosure All authors have declared no conflicts of interest.