Abstract
Ritrodrine is a beta-adrenergic agonist used for the inhibition of pre-term labor. As a potential activator of the cyclic AMP system, biochemical changes in the fetus might be anticipated after maternal treatment. Effects of maternal treatment with ritodrine on fetal rat brain development were investigated. A longterm treatment group (L) received ritodrine,3mg/kg/dose,IM q8h on days 18-22 of pregnancy.A short term treatment group (S) received one 3mg/kg I.V.dose on day 22. Controls for L and S received saline by the same procedures.Pups were delivered by C/section on day 22. Their body and brain weights and brain protein, DNA,cholesterol, glycogen,myelin basic protein and beta-adrenergic receptors (by binding of Dihydroalprenolol,DHA) were measured. No statistically significant changes were detected.Using this experimental model, there seem to be no adverse biochemical effects of Ritodrine on fetal rat brain development.
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