38. The own experience in monitoring the late radiation reaction of criticual tissues in head and neck region

Abstract

Purpose The estimation of scoring system SOMA-LENT in classification the late radiation toxicity in patients with squamous cell cancer irradiated in H&N region. Material and methods The material includes 97 patients with oral cavity, pharyngeal and supraglottic cancer T 2–4 N 0–1 irradited by conventional method (18 patients), continous accelerated irradiation CAIR (42 patients) and concomitant boost CB (37 patients). Total dose was in range 66–74 Gy. The late radiation toxicity was evaluated by SOMA-LENT system for pharyngeal and oral cavity mucosal membrane, skin, larynx, salivary glands, spinal cord. The estimation was done every 6 months after completing of radiotherapy. In statistical analysis the values were normalisated to maximal intensity of all symptoms in the scale. Results The intensity of late radiation toxicity for mucosal membrane was increasing between 12 th –18 th month after radiotherapy and next decreased from 24 after irradiation. For skin the intensity of late radiation reaction increased to 24 months after treatment. For larynx we noticed two peaks of late radiation toxicity: between 18 th –24 th month and about 54 month after irradiation. The intensity of late radiation effect for salivary glands increased to 18 month and next diminished to 60 months. For spinal cord there was observed significant progression of intensity late toxicity (mild functional) during second year after irradiation. Conclusions 1. SOMA-LENT scale seems to be adequate in the clinical practice for the estimation of late radiation toxicity of H&N region tissues. 2. Ongoing study has preliminary nature and is being continued.