38 PERIPHERAL ENDOTHELIAL FUNCTION AND CARDIOPULMONARY FUNCTION IN PATIENTS AFFECTED BY PULMONRY HYPERTENSION

Abstract

Abstract Background Pulmonary arterial hypertension (PAH) is a progressive and severe rare disease. It is a pulmonary vasculature obstructive disease that leads to right heart failure and death. Pulmonary circulation dysfunction endotelial is characterized by vasoconstriction and proliferation. Aim of study to search possible correlations between peripheral endothelian function and cardiopulmonary function in patients with suspect PAH. Materials Between February 2021 and May 2022, consecutive patients with suspect PAH underwent to assessment of peripheral endotelial function by FMD before of right heart catheterization and cardiopulmonary exercise testing. Results 46 patients (22 male, 67,9 ± 10,4 years old) with pulmonary hypertension were enrolled in the study. The following correlations were found between stress-resting absolute difference and % difference radial diameter: ramp (r: 0,69; p: 0,003 and r: 0,54; p: 0,028, respectively), Watt_AT (r: 0,63; p: 0,01 and r: 0,54; p: 0,03, respectively) and WATT_peak (r: 0,64, p: 0,009). Conclusions peripheral endothelial function may be related to funtional capacity in patients affected by pulmonary hypertension.