#3786 CORONARY ARTERY CALCIFICATION IN AN SLE PATIENT WITH RENAL: IS IT PATIENT OR DISEASE RELATED?

Abstract

Abstract Background and Aims Cardiovascular disease is one of the leading causes of death in SLE patients (Fors Nieves CE, et al. 2016). Coronary artery calcium scores can be used as a predictor CVD events, independent of traditional risk factors. CAC scores quantify the presence and extent of calcified plaque in the coronary arteries. A CAC>0 in the general population is an independent predictor of CVD mortality (PatKiani AN, et al. 2015) patients with SLE, especially those aged >45 years, have an increased prevalence of CAC and the presence of renal affection obviously increases this risk. Patients with SLE aged ≤45 years have an increased prevalence of detectable CAC compared with the general population (Yevgeniya Gartshteyn, et al. 2019). We evaluated CAC in SLE with predominantly renal affection. Method in this observational study We identified 86 patients with SLE and documented lupus nephritis by renal biopsy ISN/RPS classification 2004, without known coronary artery disease and who had a non-contrast chest CT performed as part of their clinical care, with images retrievable for calculation of CAC scores. Demographics, disease characteristics and comorbidities were ascertained and adjusted for. Results 15.1% of patients with SLE, LN (mean age 43±11 years, 84%female,) had CAC>0, 53.8% for age ≤45 years and 46.2% for age >45. Patients with SLE with CAC>0 were older and had longer disease duration and higher disease activity than patients with normal CAC (p.value 0.004, 0.004 and 0.02 respectively) Furthermore, DM was at higher incidence in normal CAC patient and all patients with CAC>0 were hypertensive. Conclusion Patients with SLE and LN have an increased prevalence of detectable CAC Our data suggest that subclinical atherosclerosis in SLE may develop early and it is directly related to disease factors as its duration and pathological activity. although, patient age is an important risk factor for developing coronary artery calcification. and this need a close monitoring and even some cardioprotective interventions.