378 SYNERGISTIC EFFECTS OF A1896, T1653 AND T1762/A1764 MUTATIONS IN GENOTYPE C2 HEPATITIS B VIRUS GENOME ON THE OCCURRENCE OF HEPATOCELLULAR CARCINOMA

Abstract

Conclusions: Prediction models that include age, platelet counts, HBVDNA, and core promoter mutations had high reproducibility and sensitivity to identify patients with risk for the development of HCC. These models may be used to extract patients at risk for HCC out of those excluded from therapy by treatment guidelines. The NUC therapy significantly reduced the incidence of HCC among patients with high risk for HCC.