376 Activation of linear ubiquitination by linear ubiquitin chain assembly complex specifically exacerbates a murine imiquimod-induced psoriasis model

Abstract

Nuclear factor-κB (NF-κB) is important in inflammatory skin diseases, including contact dermatitis (Th1 inflammation), atopic dermatitis (Th2 inflammation), and psoriasis (Th17 inflammation). In fact, molecularly targeted drugs against tumor necrosis factor (TNF), which is both upstream and downstream of NF-κB have been demonstrated to be effective in skin diseases such as psoriasis. The linear ubiquitination by linear ubiquitin chain assembly complex (LUBAC), which consists of HOIL-1L, HOIP and SHARPIN, is activating IKKβ, which is essential for TNF/NF-κB signaling.