373 Abnormal type VII collagen expression in non-lesional psoriatic skin

Abstract

The healthy-looking non-lesional (NL) psoriatic skin already carries some alterations. These alterations include extracellular matrix defects such as the disruption of laminin networks, which may lead to impaired keratinocyte adhesion to the basal membrane. This process is associated with aberrant expression of the α5β1 integrin complex and the extradomain-A-containing fibronectin (EDA+FN) around basal keratinocytes. In our previous work, in NL psoriatic skin the expression of EDA+FN was increased compared to healthy (H) skin.