372 — Polarographic adsorption of polycyclic quaternary ammonium salts and their depressor activity

Abstract

Ganglionic blocking drugs of polycyclic quarternary ammonium salts and acetylcholine chloride were examined by polarographic measurements. These drugs were much more strongly adsorbed on the negatively electrode than acetylcholine chloride. And at the same time these drugs suppressed the maximum waves of zinc, cobalt and barium ions. Among these drugs, the hexamethonium ion had the strongest effects as maximum suppressor and concerning adsorption on the negatively charged electrode at more negative potential than −2.40 V. The phenomena observed by polarographic methods agreed well with the estimation from the pharmacological experiments. This means that the polarographic results support the theoretical conclusion that the receptor sites at the membrane of ganglionic cells could be considered as negatively charged and the reactions between the receptor sites and ganglionic drugs or acetylcholine are competitive. The strength of this reaction could be estimated by the adsorption on the negatively charged electrode.