Abstract
Focal radiation necrosis of the brain (fRNB) is an adverse event (AE) following the treatment of benign or malignant brain lesions with stereotactic radiation therapy (SRT) or stereotactic radiosurgery (SRS). An increased incidence of fRNB has been reported in cancer patients (pts) treated with immune checkpoint inhibitors. Bevacizumab (BEV), a vascular endothelial growth factor-neutralizing monocolonal antibody, has shown to be an effective treatment for fRNB at a dose of 5-7.5 mg/kg Q2W x4. Based on pharmacokinetic/-dynamic data, a “low-dose regimen” of BEV (400 mg loading dose followed by 100 mg Q4W) was investigated in pts diagnosed with fRNB.
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