371. Tuberculosis and HIV Co-infection at a Tertiary Care Hospital in Thailand

Abstract

BackgroundTB is the most common opportunistic infections (OIs) among patients living with HIV and associated with morbidity and mortality. The objective of the study was to describe epidemiology and characteristics of TB in newly diagnosed HIV patients.MethodsRetrospective study was conducted at Nakhonpathom hospital, a 722-bed tertiary care hospital in Thailand during October 2016 and September 2018. The data on demography and outcome were collected.ResultsThere were 369 newly-HIV diagnosed patients. Of these, 182 patients (49.3%) presented with AIDS-defining illnesses. TB was the most common (80 patients), followed by PCP (49 patients), cryptococcal meningitis (13 patients) and invasive salmonellosis (6 patients). Medical records of 29 HIV-TB patients were incomplete and were excluded from the study. Out of 51 HIV-TB patients, the median age was 41 (range 18–63) years and 39 (76.5%) were male. The median CD4 counts was 62.5 (range 7–773) cells/µL. Twenty-six (51.0%) had only pulmonary TB, 13 (25.5%) had only extra-pulmonary TB, and 12 (23.5%) had disseminated TB. Among extra-pulmonary TB, TB lymphadenitis was seen in 13, followed by intraabdominal TB in 8, TB meningitis in 4, and TB pleura in 3 patients. The mortality rate of HIV-TB in our study was 11.8%.ConclusionTB is the most common OIs that occurs among patients with advanced HIV disease. The outcome was unfavorable, with death in 11.8%. Strategies to improve early diagnosis and treatment are warranted.Disclosures All authors: No reported disclosures.