Abstract
Barrett's esophagus (BE) is a pre-cancerous condition characterized by esophageal goblet cell metaplasia which can progress to dysplasia and ultimately adenocarcinoma. The gold standard for diagnosis is the modified Seattle protocol, where 4 quadrant forceps biopsies (FB) are taken at least every 2 centimeters (cm) throughout the BE segment. This method leaves a large amount of unsampled tissue which could be harboring more advanced dysplasia or neoplasia than what was obtained on FB. Wide Area Transepithelial Sampling (WATS3D) has been shown to increase the detection of both BE and dysplasia.
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