370P - CNS Metastases, Subtypes and Survival in Breast Cancer: A Population Based Study in Eastern Switzerland

Abstract

ABSTRACT Purpose To examine tumor characteristics and outcomes associated with central nervous system (CNS) metastases in patients with metastatic breast cancer (MBC). Methods Patients listed in the regional cancer registry of St. Gallen-Appenzell with MBC between 2003-2009 were included. Estrogen- (ER), progesterone receptor (PR) and HER2 status were collected from pathology reports. Biologic subtypes were approximated using standard immunohistochemical markers. Survival status was assessed in January 2012. Multivariate logistic regression models were used to identify factors associated with the risk of developing CNS metastases and with survival >12 months (mt) after the diagnosis of CNS involvement. Results Overall, CNS metastases were observed in 170 (22%) of 773 patients with MBC included in the study. In the multivariate model, factors associated with CNS metastases were age 12 mt. Conclusion Patients with TN or HER2-positive tumors showed increased risk for CNS metastases. However, after diagnosis of CNS metastases only surgery and radiotherapy favorably influenced survival. New approaches to control CNS disease in young patients with these subtypes need to be developed. Disclosure All authors have declared no conflicts of interest.