370MO FOLAGLI: A phase I study of folinic acid combined with temozolomide and radiotherapy to modulate MGMT gene promoter methylation in newly diagnosed MGMT non-methytated glioblastoma

Abstract

Glioblastoma is a very aggressive disease with a poor prognosis. The MGMT gene encodes an enzyme involved in DNA repair, the epigenetic silencing (by methylation) of which confers a better prognostic for GBM patients. We hypothesized that administration of folic acid could restore a methylation of MGMT promoter gene in non-methylated GBM and thus increase sensitivity to temozolomide combined with radiotherapy.