Abstract
The immunological activity of donor T-cells following allogeneic BMT is determined by the initial interaction of T-cells with antigen presenting cells (APC) in the recipient. While previous reports have established a requirement for host APC in the initiation of GvHD, we have explored the role of donor APC as positive and negative regulatory elements in the activation of allo-reactive donor T-cells. We have previously published that allogeneic donor BM enriched for CD11b- dendritic cells (DC) promotes enhanced donor T-cell chimerism and GvL, suggesting that donor DC subsets modulate immune reconstitution post-BMT (Li, Waller.
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