Abstract
Background: Understanding of serous carcinoma involving the ovary has changed greatly over recent decades. Serous ovarian carcinoma involving the ovary was previously graded using a three-tier system. Low grade serous ovarian carcinoma (LGSOC) and high grade serous carcinoma (HGSC) are now recognised as distinct and separate entities, neither of which are graded. These entities have different pathogenesis, with HGSC involving the ovary being an aggressive neoplasm, commonly originating from fallopian tube. By comparison, LGSOC is an uncommon malignancy, often occurring in the setting of a borderline serous tumour, encountered in a younger population, with a typically prolonged survival compared to HGSC. Specific prognostic variables for LGSOC are not established.
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