Abstract
Laser-induced fluorescence from normal and neoplastic tissue differs in shape and intensity and can be used for diagnostic purposes. In this view a new device, LIFE imaging system (Xillix Co., Vancouver), is available for clinical application in the tracheo-bronchial tree ad it has been used in 140 patients at high risk of lung cancer at INT of Milan (Italy). After a white light bronchoscopy, the patients were submitted to fluorescence bronchoscopy and the findings of both examinations have been classified in 3 cathegories: class I or normal, class II for alterations suggesting inf1ammation or metaplasia and class III for neoplastic mucosa. All II and III sites have been biopsied for histologic examination: a comparison between histologic results and white light or fluorescence bronchoscopy has been performed for assessing sensitivity and specificity of the two exams. Squamous intraepithelial neoplasia has been detected in 19 patients with a sensitivity of 74% for white light bronchoscopy and 100% for fluorescence bronchoscopy. Specificity of white light and fluorescence bronchoscopy was 92% and 79%, respectively. These data suggest that fluorescence bronchoscopy improves accuracy of endoscopic examination in detecting early lung cancer.
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