368 Beyond the Pill: Preliminary Data Looking at a Combination of Phosphodiesterase Inhibitors With Low Dose Bimix Intra-urethral Gel for the Management of Erectile Dysfunction

Abstract

Intracavernosal Trimix/Bimix injections (ICI) and Intraurethral Bimix Gel (BMG) have been used for many years for the treatment of erectile dysfunction (ED). Both are great therapies, but more invasive than oral phosphodiesterase inhibitors (PDE5-I). Unfortunately, PDE5-I sole therapy may not be strong enough for moderate to severe ED. A combination of PDE5-I with a low dose, needle-free, intraurethral gel may be more attractive than a difficult to stabilize, refrigeration required, needle to the penis for the treatment of ED. BMG’s versatility is such that it can be used as a sole therapy, or in combination with oral therapy, PDE5-I. This data provides preliminary data on the combination of BMG and PDE5-I for the treatment of ED. Twenty patients were chosen from a registry of 236 patients who were prescribed BMG. Patients were unsatisfied with current treatment of PDE5-I solo therapy. They were not interested in ICI. They all had attempted BMG as a solo treatment modality and reported an improvement in the quality of their erections but reported an uncomfortable “burning sensation” in the urethra with BMG at high dosages. Higher doses were necessary to achieve the appropriate erection. These patients were then instructed to take one-hour pior to intercourse either a 20mg Cialis, 100mg Viagra or a 200mg of Stendra followed by 0.25ml of BMG, 5-10 minutes prior to intercourse.