Abstract
The blood brain barrier (BBB) protects the internal milieu of the central nervous system by barring entry of most serum proteins. Perturbation of the BBB occurs with many pathologic conditions and may have prognostic significance. BBB status may also influence diagnosis and treatment of brain injury by limiting the availability of brain specific proteins in the serum and the delivery of therapeutic agents to the central nervous system (CNS), respectively. This study evaluated two putative serum markers of BBB disruption in patients with clinically defined mild traumatic brain injury (mTBI).
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