Abstract
Several different groups have independently demonstrated that non-allospecific memory T cells do not induce GVHD. The data related to the ability of allospecific memory T cells to induce GVHD have not been conclusive. In order to study this question more definitely, we have developed a novel GVHD model using TEa TCR transgenic mice as donors. TEa CD4+ TCR transgenic mice (C57BL/6 background) express a TCR that recognizes the peptide ASFEAQGLANIAVDKA in the context of I-Ab. This peptide corresponds to positions 52–68 from the alpha-chain of I-E class II molecules and is expressed in all APCs from H-2b/I-E+ strains such as CB6F1 mice.
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