(364) Administration of Pre-Operative Gabapentin to Patients Undergoing Laparoscopy: A Double-Blind, Placebo-Controlled Randomized Trial

Abstract

The objective of this study was to determine the influence of immediate pre-operative gabapentin on postoperative pain in patients undergoing laparoscopy for benign gynecologic indications. We completed a double-blind, placebo controlled, randomized trial at an academic tertiary care hospital. One-hundred-nine gynecologic patients undergoing laparoscopy between June 2015 and January 2016 were included in our study. We randomized 109 patients to receive pre-operative gabapentin (300mg) or placebo. The patients were stratified based on a history of chronic pelvic pain. Pain scores were assessed at 2, 4, 6 and 8 hours post-operatively as well as post-operative days 1-7. We found no difference between the groups in terms of age, body mass index, gravidity, parity, or past surgical history. Post-operative pain was assessed using the numeric pain rating scale (NRS), rated as 0-10, and the visual analog scale (VAS), rated as 0-100. These values were adjusted for morphine dose received. Findings included, no significant difference in pain scores at any of the immediate post-operative hours. A secondary analysis stratified by procedure, hysterectomy or operative laparoscopy, showed no significant difference in pain scores. There was also no significant difference in pain scores on post-operative days one through seven. In this study, a single dose of pre-operative gabapentin did not significantly decrease post-operative pain in gynecologic patients undergoing laparoscopy for benign indications. The study was supported in part by an award from The Penn State Hershey Department of Obstetrics and Gynecology.