Abstract
Previous studies with mice lacking epidermal macroautophagy suggest that under pro-aging stress there is a profound change in lipid metabolism and an increased susceptibility to DNA damage and cellular senescence. Thus we followed up these studies now in cohorts of young (< 8 mo) and geriatric (>16 mo) mice which did or did not lack epidermal Atg7 (Atg7 f/f: K14 cre+), and studied the consequences of chronological aging on the level of the epidermal lipidome. Additionally, we analyzed the transcriptome of corresponding cohorts of mice for genes with a function in lipid metabolism or lipid signaling for genes differentially expressed in age and/or autophagy deficiency.
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