Abstract
Although TGF-β levels are elevated in the plasma and skin lesions of psoriasis patients, the functional significance of this observation is not yet known. TGF-β activation is principally mediated by the mechanosensitive integrin αVβ6 complex, which promotes the release of the Latency-Associated Peptide (LAP). We hypothesized that the activation of αVβ6 is dysregulated in the epidermis during psoriatic inflammation resulting in increased TGF-β signaling in keratinocytes. Here, we analyzed the expression, localization and functional activation of αVβ6 integrin in healthy and psoriatic human skin, reconstructed human epidermis (RHE) and undifferentiated keratinocytes.
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