Abstract
Mesenchymal stem cells (MSCs) offer tremendous potential in regenerating diseased or injured tissues due to their ability to differentiate into various different cell types including cartilage, bone, fat and other connective tissue. Lentiviral vector transduced MSCs are of interest to gene therapy as they can be used to deliver genes to sites of injury after systemic delivery, serve as a platform for controlled therapeutic gene expression and have the potential for modification by over-expression of differentiation factors. Therapeutic use of transduced MSCs must also satisfy questions regarding biosafety such as the effect of transduction on cellular phenotype and differentiation capability and the risk of insertional mutagenesis caused by integrating viral vectors.
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