360 TLR4 Plays An Important Role In Chronic Relapsing Pruritus Induced By Subcutaneous Capsaicin Injection In Neonatal Rats

Abstract

Despite the high prevalence of chronic dermatitis and the accompanied intractable itch, therapeutics that specifically target itching have low efficacy. Although toll-like receptors (TLRs) are suggested to contribute to immune activation and neural sensitization, their roles in chronic itch in the skin remain elusive. Here, we show that the RBL-2H3 mast cell line expresses TLR4 and that treatment with a TLR4 antagonist opposes the LPS-dependent increase in mRNA levels of Th2 and innate cytokines.