Abstract
Publisher Summary The acronym, “rab” is used when four additional members of the ras gene family were isolated from a rat brain cDNA library by means of synthetic oligonucleotide probes. It is readily observed that these mammalian rab genes constituted a distinct branch of the rab superfamily, more closely related to two genes discovered in Saccharomyces. Cerevisiae. rab genes is the focus of intense research and, indeed, this branch of research has grown. Additional members are characterized by several groups: the YPT cDNA of mouse, capable of complementing that of yeast, confirmed that rab1 is the homolog of the yeast YPT gene. At present, there are some 16 members, characterized in mammals that pertain to the rab branch of the family. This figure may represent only a fraction of the total number of the existing Rab proteins, even though different approaches have often led to the rediscovery of previously known members.
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