Abstract
This chapter describes the strategies and presents the methodologies, used to assess the enzymic degradation of luteinizing hormone releasing hormone (LHRH) by discrete regions of the rat hypothalamus. The chapter reveals that to assess the physiological relevance of peptidase activity, it is important to examine enzymic activity in relation to the activity of LHRH secretory neurons. This chapter describes the approach to the assessment of hypothalamic peptidase activity acting on luteinizing hormone releasing hormone (LHRH). The chapter also discusses its possible physiological relevance as related to the activity of the LHRH hypophysiotropic neuronal system that regulates gonadotropin secretion. The chapter describes the strategies that is adaptable for the study of peptidase activities acting on a variety of neuroendocrine peptides in discrete hypothalamic regions, or, indeed, for the investigation of neuropeptidase activity at any site in the nervous system.
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