359P - Long-term observation of surgically treated oropharyngeal cancer

Abstract

Background: Oropharyngeal cancer is treated by surgery and/or (chemo-)radiotherapy. Strong therapy can lead to late toxity such as mucositis, xerostomia, and dysphagia. For the treatment of pharyngeal carcinomas, health providers should plan treatment with an aim to long-term laryngeal function maintenance. Methods: We retrospectively studied the long-term outcome of oropharyngeal cancer. We evaluated the clinical records of 157 oropharyngeal cancer patients who underwent surgery as primary treatment, from April 1992 through December 2005 at the National Cancer Center East Hospital. Results: The number of patients with stage I, II, III and IV were 12, 27, 26 and 92, respectively. The number of patients with subsites were lateral wall, anterior wall, posterior wall and superior wall were 84, 52, 4 and 17, respectively. 81 patients underwent reconstruction surgery with free frap. 19 patients underwent post-operative therapy. The 5-year and 10-year overall survival rates were 51.0 and 44.7%, respectively. 66 patients died due to oropharyngeal cancer, and 25 patients died due to other causes. 53 patients developed multiple cancers. Functional laryngeal preservation late was 78.3%. Laryngeal function was impaired by the recurrence or other cancers. Conclusions: After oropharyngeal cancer therapy, long-term observation is necessary. Legal entity responsible for the study: Takeshi Shinozaki Funding: None Disclosure: All authors have declared no conflicts of interest.