359 EXPRESSION PROFILE OF E-CADHERIN AND N-CADHERIN IN UROTHELIAL CARCINOMA OF THE UPPER URINARY TRACT AS A NOVEL PREDICTOR OF RECURRENCE FOLLOWING NEPHROURETERECTOMY

Abstract

You have accessJournal of UrologyUrothelial Cancer: Markers + Natural History & Pathophysiology1 Apr 2011359 EXPRESSION PROFILE OF E-CADHERIN AND N-CADHERIN IN UROTHELIAL CARCINOMA OF THE UPPER URINARY TRACT AS A NOVEL PREDICTOR OF RECURRENCE FOLLOWING NEPHROURETERECTOMY Mototsugu Muramaki, Hideaki Miyake, Sadao Kamidono, and Masato Fujisawa Mototsugu MuramakiMototsugu Muramaki Kobe, Japan More articles by this author , Hideaki MiyakeHideaki Miyake Kobe, Japan More articles by this author , Sadao KamidonoSadao Kamidono Kobe, Japan More articles by this author , and Masato FujisawaMasato Fujisawa Kobe, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.445AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES In normal tissues, epithelial and mesenchymal cells mainly express E-cadherin and N-cadherin, respectively; however, several recent studies have demonstrate the important role of a switch from E-cadherin to N-cadherin in cancer cells, which is regarded as one aspect of the epithelial-to-mesenhymal transition, in the malignant progression through their enhanced mortility and invasive potential. The objective of this study was to investigate the impact of the expression patterns of E-cadherin and N-cadherin on the probability of intra- and extra-vesical recurrence of urothelial carcinoma of the upper urinary treact (UC-UUT) following nephroureterectomy. METHODS Expression levels of E-cadherin and N-cadherin were evaluated by immunohistochemical staining in a consecutive series of 59 UC-UUT specimens from patients undergoing nephroureterectomy. Intra- and extra-vesical recurrence-free survival rates were calculated using the Kaplan-Meier method. Various predictive factors for postoperative recurrence were evaluated using multivariate analysis. RESULTS Median follow-up period of the 59 patients was 32 months (range, 12 – 79 months). Among these 59 patients, intra- and extra-vesical recurrence occurred in 20 (33.9%) and 19 (32.2%) patients, respectively. Low E-cadherin expression was associated with extravesical recurrence but not intravesical recurrence (p = 0.006), while high N-cadherin expression was associated with both intra- and extra-vesical recurrence (p = 0.026 and 0.017, respectively). When high risk group was defined as patients with low expression level of E-cadherin and high expression level of N-cadherin, 18 of the 59 patients (30.5%) were classified in this group. Of these 18, 12 (66.7%) and 15 (83.3%) patients developed postoperative intra- and extra-vesical recurrence, respectively. Furthermore, classification of high risk group appeared to be an independent predictive factor for both intra- and extra-vesical recurrence following nephroureterectomy (p = 0.015 and 0.002, respectively) on the multivariate analysis. CONCLUSIONS These findings suggest that reduced expression of E-cadherin and increased expression of N-cadherin is a powerful predictive factor for postoperative intra- and extra-vesical recurrence of UC-UUT, suggesting the important role of a switch from E-cadherin to N-cadherin expression in the recurrence of UC-UUT. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e146 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mototsugu Muramaki Kobe, Japan More articles by this author Hideaki Miyake Kobe, Japan More articles by this author Sadao Kamidono Kobe, Japan More articles by this author Masato Fujisawa Kobe, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...