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Abstract
Recently, molecular studies in small cell lung carcinoma (SCLC) have identified 4 subtypes defined by RNA expression of achaete-scute homologue 1 (ASCL1), neurogenic differentiation factor 1 (NEUROD1), POU class 2 homeobox 3 (POU2F3) and yes-associated protein 1 (YAP1) transcriptional regulators. However, there is scant literature regarding expression of these markers at protein/immunohistochemistry (IHC) level along with its prognostic implications. These molecular subtypes might define distinct therapeutic implications.
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