Abstract
Diabetes mellitus is an urgent global health problem imposing a significant socioeconomic burden on societies. With high recurrence rates, non-healing wounds in diabetic patients are highly susceptible for necrosis due to ischemia and often progress to lower limb amputation. Severe angiopathy with reduced angiogenesis is a major driver for diabetes associated non-healing wounds. To dissect the underlying mechanisms, we here addressed the question whether administration of skin derived ABCB5+ MSCs, precursors of perivascular fibroblasts, can rescue suppressed angiogenesis and impaired wound healing in a full thickness wound model in diabetic mice.
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