Abstract
Diabetes mellitus is an urgent global health problem imposing a significant socioeconomic burden on societies. With high recurrence rates, non-healing wounds in diabetic patients are highly susceptible for necrosis due to ischemia and often progress to lower limb amputation. Severe angiopathy with reduced angiogenesis is a major driver for diabetes associated non-healing wounds. To dissect the underlying mechanisms, we here addressed the question whether administration of skin derived ABCB5+ MSCs, precursors of perivascular fibroblasts, can rescue suppressed angiogenesis and impaired wound healing in a full thickness wound model in diabetic mice.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
