Abstract
of the serotonergic system is correlated with impulsive aggression. In the current study, we used positron emission tomography (PET) and the radioligands 18F-setoperone and 11C-SCH 23,390 to quantify 5-HT2 and D1 receptor binding, respectively, in eight subjects with MDD with anger attacks and a control population. Data were analyzed using the Simplified Reference Tissue Model, with the cerebellum as the input tissue to solve for the binding potential for 18F-setoperone and 11C-SCH 23,390 in multiple brain regions. Initial analysis did not demonstrate significant global cortical differences in 5-HT2 and D1 binding potential between subjects with MDD with anger attacks and control subjects. Subsequent data of 5-HT2 and D1 binding potential in both populations using circumscribed region of interest analysis of specific brain regions will be presented. Results will be discussed with regard to the role of 5-HT and D1 in the pathophysiology of MDD with anger attacks.
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