#356 : Concurrent Growing Teratoma Syndrome and Gliomatosis Peritonei in Childbearing Woman with Mature Ovarian Teratoma: A Case Report

Abstract

Gliomatosis peritonei (GP) is a rare clinical condition associated with ovarian teratomas of any grade, in which benign glial implants develop on the peritoneal surface of the abdomen. Growing teratoma syndrome (GTS) is a rare entity defined as the appearance of benign enlarging peritoneal implants that occur during or after chemotherapy for malignant germ cell tumors but are histologically mature teratomas without any malignant component. Complete surgical resection is essential for the diagnosis and treatment of GTS. We report an association scarcely described in the literature to date, in which both GP and GTS were observed in a patient treated with chemotherapy for immature ovarian teratoma. We encountered a patient with suspected concurrent GTS and Gliomatosis peritonei 2 months after chemotherapy, and a second-look fertility-sparing surgery confirmed the diagnosis. A tumor suspected to be GTS was observed in a nulliparous woman in her 20’s immediately after the completion of three cycles of bleomycin, etoposide, and cisplatin therapy after fertility-sparing surgery for stage IIIb ovarian immature teratoma. As ovarian germ cell tumors are characterized by a young onset, fertility-sparing surgery is performed in most cases. Total tumor resection affects the prognosis of GTS; therefore, minimally invasive surgery before tumor growth is advisable.