35351 Association between prurigo nodularis and gastrointestinal and hepatobiliary diseases in adults: A national cross-sectional study.

Abstract

Prurigo nodularis (PN) is an inflammatory skin disease that carries a significant burden of disease. Despite PN’s association with several systemic comorbidities, there are limited data on its association with gastrointestinal (GI) and hepatobiliary diseases. We analyzed the 2016 – 2018 National Inpatient Sample, a cross-sectional sample of 20% of all U.S. hospitalizations for comorbid GI and hepatobiliary diseases among patients with PN. There were an estimated 90,874,746 total hospitalizations, with 4,815 having a diagnosis of PN. The prevalence of a GI or hepatobiliary disease was higher in adults with PN (36.9%, 95% CI 33.9-40.0%) than without PN (27.7%, 95% CI 27.5-27.9%). In multivariable logistic regression models controlling for age, sex, race, and insurance type, PN was associated with having any GI or hepatobiliary disease (aOR 1.68, 95% CI 1.46-1.92). PN was associated with 11 of the 20 GI or hepatobiliary diseases examined, with primary biliary cirrhosis (aOR 17.4, 95% CI 6.1-49.8) and toxic liver disease (aOR 7.94, 95% CI 2.6-24.8) having the greatest association. Among patients hospitalized with any GI or hepatobiliary disease, PN was associated with a greater mean cost of care ($17,591 95% CI $15,551-19,632 vs $14,813, 95% CI $14,656-14,969; P = .007) and length of stay (6.95 days, 95% CI 6.29-7.61 days vs 5.27 days 95% CI 5.24-5.30 days; P < .001). PN has significant associations with several GI and hepatobiliary diseases. Patients with any comorbid GI and hepatobiliary disease have increased health care utilization in an inpatient setting.