Abstract
Hidradenitis suppurativa (HS) is a chronic inflammatory condition associated with a significant reduction in quality of life. While studies have examined inflammatory biomarkers in HS, they have not identified a correlation between these biomarkers and clinical outcomes. To evaluate this association, we used TriNetX, a global health care network of 76 million patient records. A total of 37,702 patients had ≥2 instances of ICD-10 code L73.2 for HS from 2015 to 2021 and were age-, sex-, and race-matched to healthy controls. P values were adjusted using the Benjamini-Hochberg method. Relative to controls, HS patients had higher C-reactive protein (CRP) [25.1 ± 46.6 μg/mL vs. 15.2 ± 37.7 μg/mL, p 10 μg/mL) had higher risk of VTE [RR 1.85, 95% CI 1.40-2.46], malignancy [RR 1.71, 95% CI 1.04-2.82], MI [RR 1.65, 95% CI 1.21-2.25], and mortality [RR 2.23, 95% CI 1.73-2.88] than HS patients with low CRP. In conclusion, elevated inflammatory markers in HS may increase the risk of adverse clinical outcomes.
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